Hubertus Haas Ph.D., Assoc. Prof.

EMail: hubertus.haas@i-med.ac.at
Tel.: +43/(0)512/9003-70205
Fax: +43/(0)512-9003-73100

1963, born in Kufstein, Tyrol/Austria

Workgroup

Molecular Microbiology

Research Interests

see Molecular Microbiology

Hubertus Haas

Short curriculum

1983-1988 Studies of Microbiology at the University of Innsbruck/Austria
1988 Master degree (Mag. rer. nat.), Master thesis: "Establishment of a phleomycin resistance based transformation system for Penicillium chrysogenum" at the Biochemie GmbH Kundl(Novartis) / Austria
1990 EMBO-Short-Term-Fellowship at the "Max-Planck-Institut für Molekulare Genetik" in Berlin/Germany
1991 Ph.D. degree (Dr. rer. nat.), Ph.D. thesis: "Characterization of extracellular enzymes and the encoding genes of Penicillium chrysogenum" at the Department of Microbiology (Med. School)/University of Innsbruck and at the Biochemie GmbH Kundl(Novartis) / Austria
since 1993 Assistant professor at the Department of Molecular Biology at the University of Innsbruck
1993-1994 Schrödinger Long-Term-Fellowship at the Department of Biochemistry, Columbus, Ohio/USA
1996 Höchst Award
1998 Brandl Award
1999 "Habilitation" (venia docendi) in Microbiology; Associate professor at the Department of Molecular Biology at the University of Innsbruck

Teaching

From the online catalog of the Innsbruck Medical University (in German): Current lectures

From the online catalog of the University of Innsbruck (in German): Current lectures

Publications

  1. Haas H, Redl B, Leitner E & Stöffler G (1991). Penicillium chrysogenum extracellular acid phosphatase: purification and biochemical characterization. Biochim. Biophys. Acta 1074:392-397.

  2. Haas H, Redl B, Friedlin E & Stöffler G (1992). Isolation and molecular analysis of the Penicillium chrysogenum phoA gene encoding a secreted phosphate-repressible acid phosphatase. Gene 113:129-133.

  3. Haas H, Redl B, Herfurth E & Stöffler G (1992). Purification, characterization and partial amino acid sequences of a xylanase produced by Penicillium chrysogenum. Biochim. Biophys. Acta 1117:279-286.

  4. Haas H, Friedlin E, Stöffler G & Redl B (1993). Cloning and structural organization of a xylanase-encoding gene from Penicillium chrysogenum. Gene 126:237-242.

  5. Haas H, Bauer B, Redl B, Stöffler G & Marzluf GA (1995). Molecular cloning and analysis of nre, the major nitrogen regulatory gene of Penicillium chrysogenum. Curr. Genet. 27:150-158.

  6. Haas H & Marzluf GA (1995). NRE, the major nitrogen regulatory protein of Penicillium chrysogenum, binds specifically in the intergenic promoter regions of nitrate assimilation and penicillin biosynthetic gene clusters. Curr. Genet. 28:177-183.

  7. Marx F, Haas H, Hofer S, Stöffler G & Redl B (1995). Sequence and structure of Penicillium chrysogenum phoG, homologous to an acid phosphatase encoding gene of Aspergillus nidulans. Gene 160:137-138.

  8. Marx F, Haas H, Reindl M, Stöffler G, Lottspeich F & Redl B (1995). Cloning, structural organization and regulation of expression of the Penicillium chrysogenum paf gene encoding an abundantly secreted protein with antifungal activity. Gene 167:167-171.

  9. Haas H, Marx F, Graessle S & Stöffler G (1996). Sequence analysis and expression of the Penicillium chrysogenum nitrate reductase encoding gene (niaD). Biochim. Biophys. Acta 1309:81-84.

  10. Haas H, Zadra I & Graessle S (1996). Partial sequence of the actin encoding gene (actA) of Penicillium chrysogenum. GenBank accession number U61733.

  11. Haas H, Angermayr K & Stöffler G (1997). Molecular analysis of a Penicillium chrysogenum GATA factor encoding gene (sreP) exhibiting significant homology to the Ustilago maydis urbs1 gene. Gene 184:33-37.

  12. Graessle S, Haas H, Friedlin E, Kürnsteiner H, Stöffler G & Redl B (1997). Regulated system for heterologous gene expression in Penicllium chrysogenum. Appl. Env. Microbiol. 63:753-756.

  13. Lusser A, Brosch G, Loidl A, Haas H & Loidl P (1997). A Novel Type of Histonedeacetylases: Molecular Cloning and Sequencing of HD2 of Z. mays. 17th International Congress of Biochemistry and Molecular Biology, FASEB Journal 11(9). Abstract.

  14. Lusser A, Brosch G, Loidl A, Haas H & Loidl P (1997). Identification of maize histone deacetylase HD2 as an acidic nucleolar phosphoprotein. Science 277:88-91.

  15. Haas H, Angermayr K, Zadra I, & Stöffler G (1997). Overexpression of nreB, a new GATA factor-encoding gene of Penicillium chrysogenum, leads to repression of the nitrate assimilatory gene cluster. J. Biol. Chem. 272:22576-22582.

  16. Zhou L, Haas H & Marzluf GA (1998). Isolation and characterization of a new gene, sre, which encodes a GATA-type regulatory protein that controls iron transport in Neurospora crassa. Mol. Gen. Genet. 259:532-540.

  17. Dangl M, Lusser A, Brosch G, Loidl A, Haas H & Loidl P (1998). Second family of histone deacetylases. Science 280:1167a (www.sciencemag.org). Technical comment.

  18. Angermayr K, Parson W, Stöffler G & Haas H (1999). Expression of atrC - encoding a novel member of the ATP-binding cassette transporter family in Aspergillus nidulans - is sensitive to cycloheximide. Biochim. Biophys. Acta 1453:304-310.

  19. Haas H, Zadra I, Stöffler G & Angermayr K (1999). The Aspergillus nidulans GATA-factor SREA is involved in regulation of siderophore biosynthesis and control of iron uptake. J. Biol. Chem. 274:4613-4619.

  20. Haas H (1999). GATA- factors and nitrogen metabolism in filamentous fungi. Amino Acids 17:98. Abstract.

  21. Lusser A, Eberharter A, Loidl A, Goralik-Schramel M, Haas H & Loidl P (1999). Analysis of the histone acetyltransferasae B complex of maize embryos. Nucl. Acids Res. 27:4427-35.

  22. Graessle S, Dangl M, Haas H, Mair K, Trojer P, Brandtner E, Walton JD, Loidl P & Brosch G. (2000). Characterization of two putative histone deacylase genes from Aspergillus nidulans. Biochim. Biophys. Acta 1492:120-6.

  23. Feng B, Haas H & Marzluf GA (2000). ASD4, a new GATA factor of Neurospora crassa, displays sequence-specific DNA binding and functions in ascus and ascospore development. Biochemistry 39:11065-73.

  24. Zadra I, Abt B, Parson W & Haas H (2000). AxylP promoter-based expression system and its use for antisense downregulation of the Penicillium chrysogenum nitrogen regulator NRE. Appl. Environ. Microbiol. 66:4810-4816.

  25. Oberegger H, Zadra I, Schoeser M & Haas H (2000). Iron starvation leads to increased expression of Cu/Zn-superoxide dismutase in Aspergillus. FEBS letters, 485:113-116.

  26. Dangl M, Brosch G, Haas H, Loidl P & Lusser A (2001). Comparative analysis of HD2 type histone deacetylases in higher plants. Planta 213, 280-285.

  27. Conlon H, Zadra I, Haas H, Arst HN, Jones MG & Caddick MX (2001). The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation. Mol. Microbiol. 40(2): 361-375.

  28. Oberegger H, Schoeser M, Zadra I, Abt B & Haas H (2001). SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans. Mol. Microbiol. 41(5): 1077-1089.

  29. Oberegger H, Zadra I, Schoeser M, Abt B, Parson W & Haas H (2002). Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization. Bioch. Soc. Trans. 30(4):781-783

  30. Oberegger H, Schoeser M, Zadra I, Schrettl M, Parson W & Haas H (2002). Regulation of freA, acoA, lysF, and cycA Expression by Iron Availability inAspergillus nidulans. Appl. Env. Microbiol. 68(11): 5769-5772.

  31. Haas H, Schoeser M, Lesuisse E, Ernst JF, Parson W, Abt B, Winkelmann G &Oberegger H (2002). Characterisation of the Aspergillus nidulans transporters for the siderophores enterobactin and triacetylfusarinine C. Biochem J. 371:505-513.

  32. Greene AV, Keller N, Haas H & Bell-Pedersen D (2003). A Circadian Oscillator in Aspergillus spp. Regulates Daily Development and Gene Expression. Eukaryot. Cell 2:231-237.

  33. Eisendle M, Oberegger H, Zadra I & Haas H (2003). The siderophor system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding L-ornithine N5-monooxygenase 8sidA) and a non-ribosomal peptide synthetase (sidC). Mol Microbiol 49:359-375.

  34. Haas H (2003). Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage. Appl. Microbiol. Biot. 62: 316-30

  35. Trojer P, Brandtner E.M, Brosch G, Loidl P, Galehr J, Linzmaier R, Haas H, Mair K, Tribus M & Graessle S (2003). Histone deacetylases in fungi: novel members new facts. Nucl. Acids Res., 31, 3971-3981.

  36. Oberparleiter, C., Kaiserer, L., Haas, H., Ladurner, P., Andratsch, M. and Marx, F.(2003). Active internalization of the Penicillium chrysogenum antifungal protein PAF in sensitive Aspergilli. Antimicrob. Agents Chemother 47: 3598-601.

  37. Oberegger, H., Eisendle, M., Schrettl, M., Graessle, S. and Haas, H. (2003). 4'-phosphopantheinyl transferase encoding npgA is essential for siderophore biosynthesis in Aspergillus nidulans. Curr. Genet. 44: 211-5.

  38. Eisendle, M., Oberegger, H., Buttinger, R., Illmer, P. and Haas, H. (2004) Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient pH regulatory system in Aspergillus nidulans. Eukaryot. Cell 3: 561-3.

  39. Leiter, E., Marx, F., Pusztahelyi, T., Haas, H. and Pocsi, I. (2004) Penicillium chrysogenum glucose oxidase - a study on its antifungal effects. J. Appl. Microbiol. 97: 1201-1209.

  40. Schrettl, M., Winkelmann, G. and Haas, H. (2004) Ferrichrome in Schizosaccharomyces pombe - an iron transport and iron storage compound. Biometals 17: 647-54.

  41. Nierman WC et al. (2005). Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438: 1151-1156. Erratum 2006 in Nature 439, 502.

  42. Tribus, M., Galehr, J., Trojer, P., Brosch, G., Loidl, P., Marx, F., Haas, H., & Graessle, S. (2005). HdaA, a Major Class 2 Histone Deacetylase of Aspergillus nidulans Affects Growth Under Conditions of Oxidative Stress. Eukaryot. Cell 4, 1736-1745.

  43. Fluckinger, M., Haas, H., Merschak, P., Glasgow, B.J. and Redl, B. (2004) Human Tear Lipocalin Exhibits Antimicrobial Activity by Scavenging Microbial Siderophores. Antimicrobial Agents Chemother 48: 3367-3372.

  44. Schrettl, M., Bignell, E., Kragl, C., Joechl, C., Rogers, T., Arst, H.N., Haynes, K. and Haas, H. (2004) Siderophore Biosynthesis but not Reductive Iron Assimilation is Essential for Aspergillus fumigatus Virulence. J. Exp. Med. 200: 1213-1219.

  45. Oide, S., Moeder, W., Haas, H., Krasnoff, S., Gibson, D., Yoshioka, K. and Turgeon, G.S. (2006). NPS6, Encoding a Non-Ribosomal Peptide Synthetase Involved in Siderophore-Mediated Iron Metabolism, is a Conserved Virulence Determinant of Plant Pathogenic Ascomycetes. Plant Cell 18: 2836-53.

  46. Eisendle, M., Schrettl, M., Kragl, C., Mueller, D., Illmer, P. and Haas, H. (2006). The intracellular siderophore ferricrocin is involved in iron storage, oxidative stress resistance, germination and sexual development in Aspergillus nidulans. Euk. Cell 5: 1596-603.

  47. Hortschansky, P., Eisendle, M., Al-Abdallah, Q., Schmidt, A.D., Bergmann, S., Thoen, M., Kniemeyer, O., Abt, B., Seeber, B., Werner, E.R., Kato, M., Brakhage, A.A. and Haas, H. (2007). Interaction of HapX with the CCAAT-binding complex - a novel mechanism of gene regulation by iron. EMBO J. 26: 3157-68.

  48. Kragl, C., Schrettl, M., Abt, B., Sarg, B., Lindner, H.H. and Haas, H. (2007). EstB-mediated hydrolysis of the siderophore triacetylfusarinine C optimizes iron uptake of Aspergillus fumigatus. Eukaryot. Cell 6: 1278-85.

  49. Schrettl, M., Bignell, E., Kragl, C., Sabiha, Y., Loss, O., Eisendle, M., Wallner, A., Arst, H.N. Jr, Haynes, K. and Haas, H. (2007). Distinct Roles for Intra- and Extracellular Siderophores during Aspergillus fumigatus Infection. PLOS Pathogens 3: 1195-207.

  50. Purschwitz J, Mueller S, Kastner C, Michelle Schoeser M, Haas H, Espeso EA, Atoui A, Calvo AM and Fischer R (2008). Functional and physical interaction of blue and red-light sensors in Aspergillus nidulans. Curr. Biol. 18:255-9.

  51. Blum, G., Perkhofer, S., Haas, H., Schrettl, M., Wuerzner, R., Dierich, M.P., Lass-Floerl, C. (2008). Potential Basis for Amphotericin B Resistance in Aspergillus terreus. Antimicrob. Agents Chemother. 52:1553-5.

  52. Haas, H., Eisendle, M., and Turgeon, G.S. (2008) Siderophores in fungal physiology and virulence. Annu. Rev. Phytopathol. 46:149-187.

  53. Joechl, C., Rederstorff, M., Hertel, J., Stadler, P.F.,Hofacker, I., Schrettl, M., Haas, H., and Huettenhofer, A. (2008) Small ncRNA transcriptome analysis from Aspergillus fumigatus suggests a novel mechanism for regulation of protein-synthesis. Nucl. Acids Res. 36:2677-89.

  54. Schrettl M, Kim HS, Eisendle M, Kragl C, Nierman WC, Heinekamp T, Werner ER, Jacobsen I, Illmer P, Yi H, Brakhage AA & Haas H (2008). SreA-mediated iron regulation in Aspergillus fumigatus. Mol Microbiol70:27-43.

  55. McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, Haynes K, Haas H, Schrettl M, May G, Nierman WC & Bignell E (2008). Sub-telomere directed gene expression during initiation of invasive aspergillosis. PLoS Pathog 4(9):e1000154.

  56. Seifert M, Nairz M, Schroll A, Schrettl M, Haas H & Weiss G (2008). Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis. Immunobiology 213:767-778

  57. Jöchl C, Loh E, Ploner A, Haas H & Hüttenhofer A (2009). Development-dependent scavenging of nucleic acids in the filamentous fungus Aspergillus fumigatus. RNA biology 6, :179-186.

  58. Wallner A, Blatzer M, Schrettl M, Sarg B, Lindner H & Haas H (2009). Ferricrocin - a siderophore involved in intra- and transcellular iron distribution in Aspergillus fumigatus. Appl Environ Microbiol 75:4194-4196.

  59. Sabiha Y, Abt B, Schrettl M, Moussa-TAA & Haas H (2009). The interplay between iron and zinc metabolism in Aspergillus fumigatus. Fungal Genet Biol 46:707-13

  60. Chamilos G, Bignell E, Schrettl M, Lewis RE, Leventakos K, May GS, Haas H & Kontoyiannis DP (2009). Exploring the Concordance of Aspergillus fumigatus Pathogenicity in Mice and Toll-Deficient Flies. Med Mycol 47:1-5.

  61. Thön M, Al-Abdallah Q Hortschanski P, Scharf DH, Eisendle M, Haas H & Brakhage AA (2009). The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucl Acids Res 38(4) :1098-1113.

  62. Tribus M, Bauer I, Haas H, Brosch G. & Graessle S. (2010). A conserved motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus nidulans. Mol Biol Cell Vol. 21, 345-353.

Division of Molecular Biology
(formerly Department of Molecular Biology)
Innsbruck Medical University
Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria 		Tel: +43-512-9003-70201, Fax: +43-512-9003-73100
E-Mail: mol-biol@i-med.ac.at

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